Left–Right Asymmetry: Cilia and Calcium Revisited
نویسندگان
چکیده
Leftward flow generated by motile cilia is known to underlie left-right asymmetry in vertebrate embryos. A new study now links intraciliary calcium oscillations to cilia motility and the downstream nodal signaling cascade that drives left-sided development.
منابع مشابه
Left-Right Asymmetry: Nodal Cilia Make and Catch a Wave
Asymmetric fluid flow in the mouse node initiates the development of left-right asymmetry. This flow is generated by motile cilia and is detected by immotile mechanosensory cilia, activating an asymmetric calcium spike.
متن کاملIntraciliary calcium oscillations initiate vertebrate left-right asymmetry
BACKGROUND Bilateral symmetry during vertebrate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant directional flow of extracellular fluid. However, how ciliary motility is perceived and transduced into asymmetrical intracellular signaling at the LRO remains controversial. Previous work has indicated that sensory cilia and polycystin-2 (Pkd2), a cation...
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The vertebrate body plan has conserved handed left-right (LR) asymmetry that is manifested in the heart, lungs, and gut. Leftward flow of extracellular fluid at the node (nodal flow) is critical for normal LR axis determination in the mouse. Nodal flow is generated by motile node cell monocilia and requires the axonemal dynein, left-right dynein (lrd). In the absence of lrd, LR determination be...
متن کاملThe Key to Left-Right Asymmetry
Establishment of left-right asymmetry in vertebrates involves cilia as essential components in the breaking of symmetry, an asymmetric signaling cascade, and a midline barrier that helps to maintain asymmetry. A new study suggests that a reaction-diffusion mechanism also plays a key role.
متن کاملCilia take charge in L–R asymmetry
Cilia take charge in L–R asymmetry eft–right asymmetry is determined by the distinct activities of two populations of cilia in the node of the mouse embryo, according to results from James McGrath, Martina Brueckner (Yale Univesity, New Haven, CT), and colleagues. Previous experiments suggested that ciliary movement at the node generates movement of the extracellular fluid surrounding the node,...
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ورودعنوان ژورنال:
- Current Biology
دوره 25 شماره
صفحات -
تاریخ انتشار 2015